The following antidepressants are available both with a prescription and over-the-counter: Pivagabine (Tonerg) – unknown/unclear mechanism of action.Oxaflozane (Conflictan) – 5-HT 1A, 5-HT 2A, and 5-HT 2C receptor agonist.Medifoxamine (Clédial, Gerdaxyl) – weak serotonin–dopamine reuptake inhibitor (SDRI) and 5-HT 2A and 5-HT 2C receptor antagonist.Indeloxazine (Elen, Noin) – serotonin releasing agent (SRA), NRI, and NMDA receptor antagonist.Etryptamine (Monase) – non-selective serotonin receptor agonist, SNDRA, and weak RIMA.α-Methyltryptamine (Indopan) – non-selective serotonin receptor agonist, serotonin–norepinephrine–dopamine releasing agent (SNDRA), and weak RIMA.Ketamine (Ketalar) – non-competitive NMDA receptor antagonist.Tianeptine (Stablon, Coaxil, Tianeurax) – weak and atypical μ-opioid receptor agonist, NMDA, Serotonin-Reuptake-Enhancer.Esketamine (Spravato) – non-competitive NMDA receptor antagonist.Agomelatine (Valdoxan) – 5-HT 2C receptor antagonist and MT 1 and MT 2 receptor agonist.Quetiapine (Seroquel) – approved as a monotherapy for bipolar depression.Lurasidone (Latuda) – approved as a monotherapy for bipolar depression.Lumateperone (Caplyta) – approved as a monotherapy for bipolar depression.Amisulpride (Solian) – approved in low doses as a monotherapy for persistent depression.Bifemelane (Alnert, Celeport) – RIMA, irreversible inhibitor of MAO-B, and weak NRI.These drugs are sometimes described as reversible inhibitors of MAO-A (RIMAs). Monoamine oxidase inhibitors (MAOIs) Irreversible Non-selective Mianserin, mirtazapine, and setiptiline are also sometimes described as noradrenergic and specific serotonergic antidepressants (NaSSAs). Tofenacin (Elamol, Tofacine) – actually not a TCA but a tricyclic-like antidepressant.Tiazesim (Altinil) – actually not a TCA but a tricyclic-like antidepressant.Melitracen (Dixeran, Melixeran, Trausabun)Īmineptine (Survector, Maneon) and tianeptine (Stablon, Coaxil) are technically TCAs but are atypical, and are grouped elsewhere.Amitriptylinoxide (Amioxid, Ambivalon, Equilibrin).Modafinil (Provigil) – actually a selective dopamine reuptake inhibitor plus other actions.Amphetamines (e.g., Adderall, Dexedrine, Vyvanse) – actually norepinephrine–dopamine releasing agents (NDRAs).Bupropion (Wellbutrin, Elontril) – also a non-competitive antagonist of nicotinic acetylcholine receptors.Norepinephrine–dopamine reuptake inhibitors (NDRIs) Viloxazine (Vivalan) – also a 5-HT 2B receptor antagonist and 5-HT 2C receptor agonist. Teniloxazine (Lucelan, Metatone) – also a 5-HT 2A receptor antagonist. Norepinephrine reuptake inhibitors (NRIs)
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